Stress vaccine will alter brain chemistry

Daily Mail
02.08.2010
By Rachel Quigley

Jab that could put a stop to stress without slowing us down

Forget the age-old remedies of yoga, meditation or popping pills. Relieving chronic stress could soon be as simple as having an injection, according to scientists.

Academics say they are close to developing the first vaccine for stress - a single jab that would help us relax without slowing down.

After 30 years of research into cures for stress, Dr Robert Sapolsky, professor of neuroscience at Stanford University in California, believes it is possible to alter brain chemistry to create a state of ‘focused calm’.

Professor Sapolsky claims he is on the path to a genetically engineered formula that would remove the need for relaxation therapies or prescription drugs.

Chronic stress, as opposed to everyday worries, is linked to illnesses ranging from diabetes to heart attacks. Professor Sapolsky, who first observed the damage caused by stress on animals in Kenya, has been studying hormones called glucocorticoids, which are part of the body’s immune system and help fight cancer and inflammation.

After early setbacks, the Stanford team has adapted a herpes virus to carry engineered ‘neuroprotective’ genes deep into the brain to neutralise the rogue hormones before they can cause damage. The virus is now shown to work on rats.

‘To be honest, I’m still amazed that it works,’ Professor Sapolsky told Wired magazine recently.

He warned that human trials are years away, but added: ‘We have proved that it’s possible. We can reduce the neural damage caused by stress.’

Last week, a Stanford University colleague, who called the potential vaccine ‘the Sapolsky shot’, said: ‘In humans this engineered virus would short-circuit the neural feedback caused by stress, that lingering feeling of tension after a crisis has passed.

‘It would leave you fresher and ready to deal with another threat, so you can maintain your drive, but with more focused calm rather than bad temper and digestion.

‘This could change society.’ Professor Sapolsky’s preparatory work was published last October by the U.S. National Institutes of Health.

Full article

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